Calu-3 cells are characterized as a human bronchial cell line composed of serous cells of airway submucosal glands that are responsible for secreting electrolytes that facilitate airway hydration. This study analyzes the effect of epinephrine on Calu-3 electrolyte transport. Results found that epinephrine stimulated anion secretion through two different channels: cystic fibrosis transmembrane conductance regulator and a Ca2+ activated Chlorine channel, in turn altering mucociliary clearance. Treating Calu-3 cells with epinephrine also resulted in increased cAMP and Ca2+. [LINK]
Calu-3 is a tumorigenic cell line that was established from the lung tissue a 25-year-old Caucasian male with adenocarcinoma. The patient had been treated with Cytoxan, Bleomycin, and Adriamycin before the tissue sample was taken. Calu-3 has a hypotriploid stemline chromosome number and expresses antigens blood type A and Rh+. Calu-3 cells display an epithelial morphology and adherent cultural properties. The Calu-3 cell line can be used to study lung cancer by following in vivo or in vitro transfection methods, and Altogen Biosystems has a Calu-3 xenograft model and a Calu-3 Transfection Reagent commercially available.
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