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Xenograft Models and Calu-3 Resources from Altogen Biosystems

Altogen Biosystems is a global provider and custom research organization for genetic research. Biological services and other experiments include ELISA testing, cell transfection optimization, stable transfection of cells, RNAi testing and more. Dedicated to helping customers with state-of-the-art and specialized services, Altogen Biosystems strives to advance modern clinical discoveries. Visit the official xenograft catalogue for a Calu-3 xenograft model.

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Calu-3 Cells Respond to Epinephrine

Calu-3 cells are characterized as a human bronchial cell line composed of serous cells of airway submucosal glands that are responsible for secreting electrolytes that facilitate airway hydration. This study analyzes the effect of epinephrine on Calu-3 electrolyte transport. Results found that epinephrine stimulated anion secretion through two different channels: cystic fibrosis transmembrane conductance regulator and a Ca2+ activated Chlorine channel, in turn altering mucociliary clearance. Treating Calu-3 cells with epinephrine also resulted in increased cAMP and Ca2+. [ LINK ]
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Calu-3 Cell Line

Calu-3 is a tumorigenic cell line that was established from the lung tissue a 25-year-old Caucasian male with adenocarcinoma. The patient had been treated with Cytoxan, Bleomycin, and Adriamycin before the tissue sample was taken. Calu-3 has a hypotriploid stemline chromosome number and expresses antigens blood type A and Rh+. Calu-3 cells display an epithelial morphology and adherent cultural properties. The Calu-3 cell line can be used to study lung cancer by following in vivo  or  in vitro transfection methods, and Altogen Biosystems has a Calu-3 xenograft model  and a Calu-3 Transfection Reagent  commercially available.
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Calu-3 Transfection Reagent (Lung Carcinoma Cells, HTB-55)

The Calu-3 cell line was derived from the carcinomatous lung tissue of a 25 year old Caucasian male suffering from adenocarcinoma. Before the cell line was established the patient had received therapy with bleomycin ,  cytoxan, and adriamycin. The tumorigenic, epithelial cells of the Calu-3 cell line are now used to produce a  transfection host model for various types of lung cancer as well as other biomedical research. The Calu-3 transfection reagents established by  Altogen Biosystems  allow an intracellular delivery of  pDNA, mRNA and  siRNA and the recombinant protein expression desired in certain research.  Calu-3 Transfection Reagent (Lung Carcinoma Cells, HTB-55)
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